Sds information may include instructions for the safe. The information contained in the sds is largely the same as the msds, except now the sdss are required to be presented in a consistent userfriendly, 16section format. Cisplatin cas 15663271 calbiochem msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. The safety data sheets for many hds recommend sodium hypochlorite solution as an appropriate. Teva cisplatin msds cisplatin and diarrhea alimta cisplatin lung cancer. There is some evidence that increased methylation is one mechanism behind this resistance, stemming from individual studies, but approaches based on matched primary and metastatic patient samples. Cisplatin is particularly effective against testicular cancer. The most common adverse effects reported in with clinical use of cisplatin include severe. Jul 01, 2019 cisplatin is one of the best and first metalbased chemotherapeutic drugs see fig. Cisplatin gains entry into tubular cells via uptake by the oct2 system on the basolateral membrane of proximal tubular cells. Ciswel cisplatin injection manufacturer in india getwell. The subject of mixedvalance pt compounds is an example.
Cisplatin, referred to by chemical name as cisdiamminedichloroplatinum ii, is anticancer, neutral and dna destroying agent that is square planar platinum ii complex and contains 2 ligands of chloride in a cis configuration orientation. Cisplatin, cisplatinum or cisdiamminedichloroplatinumii cddp is a platinumbased chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e. The type of container had no effect on cisplatin decomposition. In lung cancer cells, cisplatin decreases phosphorylation. Frozen aliquots should only be used once after thawing. Us62555b1 fine cisplatin powder and process for the. After undergoing hydrolysis, it reacts with dna to produce both intra and interstrand crosslinks. Yellow powder, yellow or orangeyellow crystals monographs. Enter agent into mychem inventory, the online uw chemical inventory system. Cisplatin is a platinumcontaining compound that acts as a dnacrosslinking agent and interferes with replication and transcription, culminating in apoptosis. Identification of the substancepreparation and the companyundertaking manufacturer. Other doses and combination regimens have been used.
These crosslinks appear to impair replication and transcription of dna. Personal protective equipment ppe double nitrile gloves or compatible. Standard operating procedure for cisplatin in animals. Package insert of accord healthcares cisplatin injection. Fluka 33422 page1 of 8 sigmaaldrich safety data sheet version 3. Cisplatin cisdiamminedichloroplatinumii cas number. Appendix c to policy hm08026 standard operating procedure. Safety data sheets free sds database chemical safety. A safety data sheet sds, material safety data sheet msds, or product safety data sheet psds is a document that lists information relating to occupational safety and health for the use of various substances and products. Cisplatin fda prescribing information, side effects and uses. Cisplatin injection fresenius kabi usa, llc revision. Before handling, refer to the safety data sheet sds provided.
Adobe acrobat reader dc software is the free global standard for reliably viewing, printing, and commenting on pdf documents. Cisplatin administration results in significant increases in the kidney weight as a percentage of the total body weight, urine. Teva cisplatin msds doctor answers on healthcaremagic. Hindpaw mechanical hypersensitivity for at least 15 days after. The cisplatin, with the cas registry number 15663271,is also known as cisdiaminedichloroplatinumii. Cisplatin injection bp 1 mgml, 10 ml, 25 ml and 50 ml msds. No precipitation at 4c was observed within the time. Upon receiving this product it is necessary to aliquot and freeze at 20.
Cisplatin injection is a clear, colorless, sterile aqueous solution. Cisplatin is a platinumbased agent whose nephrotoxicity is thought related to the chloride in the cis position. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. The present invention relates to a novel fine cisplatin powder utilized as an anticancer agent. Warning cellidtm cisplatin is a mutagenic and carcinogenic agent. Osha, cma, ansi, canadian whmis standards, european. This may include precautions for work with volatile chemotherapy drugs details given in iii. Use of zebrafish larvae lateral line to study protection against.
Material safety data sheet of cisplatin abmole bioscience. Cisplatin cas 15663271 calbiochem 232120 merck millipore. Determine any special procedures and precautions needed for the agents used. Package insert of accord healthcares cisplatin injection, 1. Accidental release measures contain spill and collect, as appropriate. Cisplatin induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the fasfas ligand system. The active ingredient, cisplatin, is a yellow to orange crystalline powder with the molecular formula ptcl. Very hazardous in case of skin contact irritant, of eye contact irritant, of ingestion, of inhalation. Use sodium thiosulfate for the prevention of cisplatin induced ototoxicity in children and adolescents with nonmetastatic hepatoblastoma strong recommendation high quality evidence 4.
It belongs to the product categories of ammine metal halide. Mutagenesis cisplatin can cause fetal harm when administered to a pregnant woman. Cisplatin, a class of platinumcontaining anticancer drugs for the treatment of solid tumors, is a substrate of oct2 and mate1mate2k. Sigmaaldrich offers a number of cisplatin products.
Each 50 ml, 100 ml or 200 ml amber vial of cisplatin injection contains. Cisplatin may cause fetal harm if administered to a pregnant woman. From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel pt antitumor agents, the socalled platinum pyrimidine blues. Cisplatin cisplatinum, cisdiamminedichloroplatinum ii, cddp is an inorganic platinum complex, which is able to inhibit dna synthesis by conforming dna adducts in tumor cells. This material safety data sheet does not constitute the guaranty or specifications of the product. Sdss formerly msdss or material safety data sheets for each hazardous chemical to downstream users to communicate information on these hazards. She used a horizontal laminarflow hood that directed the airflow. We have a range of complex generics and drug delivery based formulations. Getwell pharmaceuticals 474, udyog vihar, phasev, gurgaon 122016, haryana, india. And now, its connected to the adobe document cloud. Discovery the discovery of cisplatin is well documented 9 and. It was the first member of its class, which now also includes carboplatin and oxaliplatin. One of the most widely used and most potent chemotherapeutic agents.
Cisplatin activates ferroptosis and induces autophagy. H300, h318, h350 for the full text of the h statements mentioned in this section, see section 16. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. Differential methylation epic analysis discloses cisplatin. The hemolytic process reverses on cessation of therapy. Contact with this material in high concentrations can cause burns. The first metal based anticancer drug sciencedirect. For research use only, not for human or veterinary use. In lung cancer cells, cisplatin decreases phosphorylation of pi3k, akt, and foxo3a and induces apoptosis. Chemical hazard, click to download safety data sheet. Jun 19, 2019 cisplatin was the first member of a class of anticancer drugs, which now include carboplatin sc202093 and oxaliplatin sc202270, that form dna adducts resulting in apoptosis. Structured product labelling of accord healthcares cisplatin injection, 1 mgml, 50. Cellular apoptosisnecrosis develops due to endoplasmic reticuluminduced stress, mitochondrial injury pathways, and a death receptor pathway. Keywords animal models, cisplatin, otoprotection, ototoxicity, zebrafish.
Each 50 ml or 100 ml amber vial of infusion concentrate contains. Prevention of cisplatininduced ototoxicity in children and. Getwell oncology in india is a manufacturer and supplier of cisplatin injection ciswel at a cost effective price. Cisplatin is a chemotherapy medication used to treat a number of cancers. Dailymed cisplatin injection, powder, lyophilized, for. Cisplatin induces crosslinks between guanine bases on dna. Show this safety data sheet to the doctor in attendance. Reference numbers 1931a neulasta and pegfilgrastim biosimilars 1931a sgm p2019b. Ensure the agent sdsmsds is available to staff at all times. Sdss are a widely used system for cataloguing information on chemicals, chemical compounds, and chemical mixtures. Cisplatin has a number of side effects that can limit its use. Cisplatin cas 15663271 quick links references download sds msds certificate of analysis. Before research use of highly toxic chemicals, please complete this form and have it approved by your supervisor. Yurong lai, in transporters in drug discovery and development, 20.
Cisplatin is a platinumbased crosslinking agent that exhibits anticancer chemotherapeutic activity. Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp. The solubility of cisplatin at 4c was also studied for possible precipitation. A safety data sheet, or sds, is a standardized document that contains occupational safety and health data. Cisplatin is mutagenic in bacteria, produces chromosome aberrations in animal cells in tissue culture and is teratogenic and embryotoxic in mice. It is given by injection into a vein common side effects include bone marrow suppression, hearing problems, kidney damage. The international hazard communication standard hcs mandates that chemical manufacturers must communicate a chemicals hazard information to chemical handlers by providing a safety data sheet. Personal protective equipment ppe double nitrile gloves or compatible chemicalresistant gloves, chemical safety goggles.
Oct2 is expressed in the basolateral membrane of proximal tubules and mediates the transport of cisplatin from the blood to. Appendix c to policy hm08026 standard operating procedure sample page 1 standard operating procedure sample. Cisplatin supplier cas 15663271 cddp tocris bioscience. Cisplatin has left its mark also on areas that are generally considered largely inorganic. Cisplatin is responsible for the cure of over 90% of testicular cancer cases and it plays a vital role in the treatment of cancers such as ovarian, head and neck cancer, bladder cancer, cervical cancer, melanoma, lymphomas, as well as several others 3, 4, 7, 8. Cisplatin cas 15663271 sdssafety data sheet msds download. Cisplatin for injection has been administered at 75 mgm. Material safety data sheet msds caustic soda naoh bagian 1.
Prevention of cisplatininduced ototoxicity in children. The fine cisplatin powder obtained in the present invention does not cause secondary agglomeration, is excellent in fluidity and easily handleable in the pharmaceutical preparation step. Chemotherapy and other hazardous drugs safe use guidelines. Cisplatin and dimethyl sulfoxide react to form an adducted. Download here free healthcaremagic app to ask a doctor. Cisplatin cas 15663271 scbt santa cruz biotechnology. Cisplatin for injection has been administered at 50 mgm.
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